Introduction:
For this project, we researched a specific disease and created a visual detailing the basics of it, treatments, and how it goes hand and hand with protein synthesis. In our case, we chose Parkinson's disease and made a poster describing the basics of it, treatments, and how it specifically relates to protein synthesis.
This is the final product which is a poster.
If you can't see the words clearly, the content is listed below:
-Seligiline - Anti-depressant
-Rivastigmine - Treats Dementia
-Benztropine - Anti-Tremor
Here is the paragraph about how transcription and translation work. All the important vocabulary is bolded.
The DNA is the template. RNA polymerase takes DNA and unzipped double helix. Then it separates both sides and replaces one side with mRNA. This is known as Transcription. Transcription occurs in the nucleus. Then it moves out into the cytoplasm. Amino Acids then bond with tRNA.The tRNA prongs are known as anti codons and the mRNA prongs are known as codons. Then, the tRNA attaches to mRNA. mRNA with tRNA are fed through the ribosomes and the amino acids are connected to form long line chains called polypeptide chains. Those polypeptide chains are folded into alpha helix or beta sheets. Many alpha helix and beta helix come together and are form domains in the and the then form proteins. This is the process known as Translation. The reference sequence of the mRNA for parkinson's is GCG UCU CCG UGG CGG GGU UCA and the reference for the protein is Cgc Aga Ggc Acc Gcc Cca Agt. The amino acid sequence ALA SER PRO TRP ARG GLY SER.
If you can't see the words clearly, the content is listed below:
- What is it - Parkinson's disease is a long-term disorder occurring in the central nervous system that affects movement, that may include trembling. PINK1 is being misprogrammed to target serine/threonine kinase domains.
- What parts of the body does it affect, symptoms - This affects the motor (or movement) system. Some symptoms are shaking, difficulty with walking, dementia, depression, and sleep and emotional problems.
- What protein is affected - PINK1 protein.
- Who is likely to get it - Advancing age, sex (men are more likely), Family History, Agricultural Work, Genetic Factors, Head Trauma, and many more.
- What are the treatments or cures?
-Seligiline - Anti-depressant
-Rivastigmine - Treats Dementia
-Benztropine - Anti-Tremor
Here is the paragraph about how transcription and translation work. All the important vocabulary is bolded.
The DNA is the template. RNA polymerase takes DNA and unzipped double helix. Then it separates both sides and replaces one side with mRNA. This is known as Transcription. Transcription occurs in the nucleus. Then it moves out into the cytoplasm. Amino Acids then bond with tRNA.The tRNA prongs are known as anti codons and the mRNA prongs are known as codons. Then, the tRNA attaches to mRNA. mRNA with tRNA are fed through the ribosomes and the amino acids are connected to form long line chains called polypeptide chains. Those polypeptide chains are folded into alpha helix or beta sheets. Many alpha helix and beta helix come together and are form domains in the and the then form proteins. This is the process known as Translation. The reference sequence of the mRNA for parkinson's is GCG UCU CCG UGG CGG GGU UCA and the reference for the protein is Cgc Aga Ggc Acc Gcc Cca Agt. The amino acid sequence ALA SER PRO TRP ARG GLY SER.
Content:
Nucleus - The center, base, and most important part of an object.
Translation - The process in which a polypeptide chain is formed. See Figure 1 for details. mRNA - Short for Messenger RNA. mRNA carries parts of DNA code to other parts of the cell for processing. Codons/Anti-codons - A set of three nucleotides that base-pair with their opposite during processing. See Figure 3 for details. Transcription - The process of unwrapping DNA and making a copy of the DNA and combining it with mRNA. See Figure 4 for details. tRNA - tRNA stands for Transfer RNA. This type of RNA carries amino acids to the Ribosome to form polypeptide chains. See Figure 1 for details. Polypeptide chain - The chain created by transcription that goes through four stages to become a protein. After being created, it is named structure 1. It then forms using alpha and beta sheets to become structure 2. Domains are formed during structure 3 and in structure 4, it finally becomes a protein. See Figure 6 and 7 (Our poster, look below) for details. |
DNA - A nucleic acid present in nearly all living organisms as the main component of chromosomes. This type of nucleic acid carries genetic information.
RNA Polymerase - The enzyme that extracts the DNA template and replaces one side with mRNA. See Figure 2 for details. Ribosome - A particle found in the cytoplasm that consists of RNA and proteins. This particle transfers RNA to form polypeptide chains. Amino Acid - The compounds that make up proteins. It is made by a carboxyl group, an amino group, and a side chain. See Figure 5 for details. Folding - When polypeptide chains turn into alpha helixes or beta sheets, they undergo a process called folding. Protein - Large compounds formed from long polypeptide chains that are essential to any living organism. |
Reflection:
This was a very well executed project. Two things that I think that I did well were the fact that I was very active in discussion and work during the project. I was constantly invested in the assignments and knew what I was doing or what to do. If I was not doing work at the time, I had a plan that I was following. In summary, I was always on-task. Another thing that I think that I did well was the fact that I worked very hard. On the day before our original presentation date, I was very focused and did not rest until we had finished our poster. I was extremely dedicated to this project.
Although I did excel in some areas, there were also some that I could improve on. One thing I could've done during this project is trying to make our project as good as we could instead of stopping at a decent one. Since we were a few days ahead of schedule, we could've worked on adding more extra factors that would've made a better result. Another thing that we could've done was make sure our group was in good communications and terms. I feel like our group did well, but if we communicated with each other better we would've gotten the project done faster and it would've been better quality. Although there are some things that I wish I did better, I am overall proud of my work on this project.
Although I did excel in some areas, there were also some that I could improve on. One thing I could've done during this project is trying to make our project as good as we could instead of stopping at a decent one. Since we were a few days ahead of schedule, we could've worked on adding more extra factors that would've made a better result. Another thing that we could've done was make sure our group was in good communications and terms. I feel like our group did well, but if we communicated with each other better we would've gotten the project done faster and it would've been better quality. Although there are some things that I wish I did better, I am overall proud of my work on this project.